If elected for the third successive term, Bera would become the longest serving Indian-American Congressman ever.
Khanna, the democratic party candidate from California s 17th District, was leading with 58 per cent votes at 50,952 after 72 per cent of the votes were counted.
His closest rival Mike Honda, also of the Democratic Party, had so far garnered 42 per cent of the votes.
Interestingly, the outgoing US President Barack Obama had endorsed Harris, Krishnamoorthi and Bera.
Senator Bernie Sanders and former US President Jimmy Carter had endorsed Jayapal.
Harris, who was born in Oakland, California, is the daughter of an Indian mother who emigrated from Chennai in 1960 and a Jamaican American father.